× Tsuna & Kyoko:
If Tsuna were a prince, Kyoko would definitely be his princess. So far, Tsuna only has eyes for Kyoko as his wife. He has a huge crush on her that he's too afraid to admit unless he's in Dying Will mode but even at that time, Kyoko is too oblivious to notice anything. In chapter 6, Nana thinks that Kyoko is Tsuna's girlfriend and that it must be a pain to be paired with such a useless son. Later in the chapter, when she is shot with the DW Bullet, she tells Tsuna's mom to take back what she said about them being a couple but in reality, she was actually telling her to take back what she said about Tsuna being useless. As the story progresses, it's hard to tell whether Kyoko shares the same feelings for Tsuna but I'm pretty sure she does.

× Tsuna & Haru:
Their relationship started out shaky at first due to an incident involing Reborn. But after being saved by Tsuna twice, she had fallen in love with him even though Tsuna doesn't share the same feelings as her. Though Haru tries her best to win Tsuna's affection, it definitely is a one-sided relationship between the two. Through-out the story, Tsuna appreciates all of her hard work and there is a special place in his heart for her, but it will most likely be nothing more than that since he has strong feelings for Kyoko. I'm sure that if Haru were to ever find out Tsuna's true feelings, that she would support his decision.

× Tsuna & Takeshi:
You can say that Tsuna and Takeshi's relationship is much more calmer than the one he has with Hayato. When Tsuna first met Takeshi, he came to admire him because of his popularity with everyone in school. But it was actually the other way around after Takeshi witnessed Tsuna's match with Mochida. Tsuna originally didn't want Takeshi part of his mafia family due to the fact that he was too good of a person. But after Takeshi passes Reborn's test, he assumes the mafia is some sort of game they all play from time to time(in the Future arc, he's just as naive). Overall, Takeshi is on the same level of friendship as Hayato, protecting Tsuna and the other when danger is near.

× Tsuna & Hayato:
When Tsuna and Hayato first meet eye to eye, they don't exactly hit it off as friends. Infact, Hayato wanted to take the title of becoming the 10th generation boss for the Vongola family. Hayato challenges him to a match which Tsuna wins with the help of the Dying Will, of course. Til then, Hayato has stated to protect and be loyal to Tsuna and from there, has probably become his closest friend. In a few chapters, there are times when Hayato gets upset or jealous when his efforts go ignored and the attention has been focused on someone like Takeshi.^^; You can tell that Tsuna really does care for Hayato since he constantly worries about him. Hayato is the kind of guy to get into a bunch of trouble so Tsuna has an excuse to be worried!

× Hayato & Takeshi:
Though Takeshi is pretty much friendly with everybody he meets in Tsuna's family, Hayato has a hard time getting along with him(or anyone for that matter besides Tsuna). Hayato constantly competes with him for the place of Tsuna's right-hand man but Takeshi assumes it's some sort of game they all play so he doesn't really take it seriously as him. Their personalities clash so there are times where it's hard for them to work together or to the point where Hayato just doesn't want anything to do with Takeshi at all. But if there's a situation that's too hard for both of them to handle individually, they decided to throw away their differences and work together. From observing Hayato's behaviour, I don't think he hates Takeshi but more jealous as he sees him on the same level as becoming Tsuna's right-hand man.

× Hayato & Bianchi:
I'd be lying if I said these two would be a perfect example of a bickering brother and sister relationship. It's much different than that because half of the time, Hayato is always avoiding his sister due to traumatizing childhood events so there's not much fighting going on to begin with. Hayato has lived with sister until he was 8 years old and at the time, would probably never forget the days that his sister tortured him with her horrible cooking(he was 6 years old at the time and getting ready for a grand piano performance). After seeing her arrival at the Sawada household, he and Tsuna figure out a way to get rid of her which pretty much ends in failure. Though despite it all, Bianchi is a VERY caring sister but it's probably just hard for Hayato to figure that out right now as he only sees the darkside of her.^^;

× Hayato & Dr.Shamal:
In chapter 19, you can see that these two have known each other from before. Shamal used to work with Hayato's family so he knows a few things about them. At first, you're only given the impression that Hayato has much hate for Shamal since he's such a pervert but in chapter 88, you get a glimpse of the past. When Hayato was very young, he used to imitate the things that Shamal did. From the hairstyle to wanting to use the Trident Mosquito skill. Shamal thought that type of skill didn't suit him so he taught him how to use small dynamite. After some practice, he approached Shamal thinking he got the hang of it though the doctor refused to teach him anything else, saying Hayato couldn't see it(probably the right way of using the skill). He tries really hard to improve his skills and Shamal knows this but most likely wants Hayato to learn this for himself without his help.

× Lambo & I-Pin:
This is actually a funny little relationship. I-Pin's first impression was that Lambo was a Broccoli monster. Her second impression was that he was just an idiot. Angry by this, Lambo gets her back by always calling her a "Tail Head". This relationship would probably be a good example of a quarreling little brother and sister. Most of the fights that are started are due to Lambo's bratty attitude of course, so I-Pin shows him a thing or two by beating him senseless until he apologizes. There are a few rare times where you'll actually see them getting along. It's funny though, you hardly ever see them talk in their adult forms.^^;

× Kyoko & Hana:
The two of them are the best of friends even though it may seem that their personalities don't mesh well together from Tsuna's point of view. But they do share a special bond as Hana is always looking out for Kyoko and warning her of any danger. In the Future arc, it was Hana who told Kyoko that she can come to her if she needed anything.

× Kyoko & Haru:
When they first met, they hit it off as friends instantly much to Tsuna's surprise. Even though Haru is very forward with Tsuna on getting his affection, Kyoko shows no signs of rivalry or jealously. Infact, she's pretty oblivious about Haru's love-love feelings for Tsuna and thinks that they both care for Tsuna in the same matter. The two both have the same taste in sweets and are usually making crafty items for Tsuna and the other boys when they're not around.

× Mukuro & Chrome:
It's hard to tell whether Mukuro actually cares for Chrome as he already stated in the Kokuyo arc that his 'friends' were merely tools but she may be a different case. Chrome on the other hand does have feelings(not love) for Mukuro because he was the only one who understood what she was going through during her time in the hospital. The fact that Mukuro helped her through hard times makes her feel that she must do everything she can to carry out his orders.

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